Abstract
A simple, straightforward and versatile multicomponent protocol for the synthesis of indanone-fused spirooxindole derivatives has been developed. The strategy involves the one-pot three-component reaction of heterocyclic ketene aminals, 1H-indene-1,3(2H)-dione and the dicarbonyl compounds isatins or acenaphthenequinone in an ethanol/water medium catalysed by p-TSA at reflux. Mild reaction conditions, operational simplicity, wide substrate scope and overall excellent yields make this method highly efficient for the library synthesis of indanone-fused spirooxindole.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.