ChemInform Abstract: Three‐Component Coupling Sequence for the Regiospecific Synthesis of Substituted Pyridines.

Abstract

AbstractThe de novo synthesis proceeds through the nucleophilic addition of a dithiane anion to an α,β‐unsaturated aldehyde or ketone, followed by the Ti‐mediated carbometalation of the lithium alkoxides derived from the resulting alcohols (III) with Tms‐imines (generated in situ by the low‐temperature reaction of LiN(Tms)2 with an aldehyde), and the Hg(II)‐ or Ag(I)‐mediated ring closure.