Abstract
Several thiazolidinedione derivatives (3-7) were designed and synthesized as candidate thyromimetic drugs. Among them, the dihydrogenated compounds, such as 5-2-[[4-(3-tert-butyl-4-hydroxyphenyl)oxy-3, 5-diiodophenyl]ethyl]-2, 4-thiazolidine-dione (6d) and its 3-isopropyl analog (7b), exhibited potent thyroid hormone receptor α1 (TRα1) activation activity.
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