Abstract
Trifluoromethylation of the acyclic derivative of D-lyxose, 3, with trifluoromethyltrimethylsilane in the presence of tetrabutylammonium fluoride yielded a mixture of trifluoromethyl adducts, 5a and b, which was converted to 6,6,6-trifluoro-L-fucose 9a and 6-deoxy-6,6,6-trifluoro-D-altrose 9bvia selective oxidation of the primary hydroxy group involving treatment of the trimethylsiloxy derivatives, 7a and b, with Collins reagent.
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