ChemInform Abstract: Synthesis of Quinolino[2′,3′:8,7]cyclooct[b]indole.

Abstract

A rapid and efficient synthetic route for the synthesis of 7,8,9,10-tetrahydroquinolino[2 ′ ,3 ′ :8,7] cyclooct[b]indole analogues has been developed by reaction of 1-oxo-1,2,3,4,5,6-hexahydrocyclooct[b]indole with anthranilic acid and 3-amino pyrazine acid under POCl3 condition and the synthesis of 7,8,9,10-tetrahydroquinolino[2 ′ ,3 ′ :8,7]cyclooct[b]indole-6-carboxylic acid has been designed by reaction of 1-oxo-1,2,3,4,5,6-hexahydrocyclooct[b]indole with isatin in the presence of NaOH via Pfitzinger reaction. These methods are more satisfactory in terms of the yield and simple one-pot operation. Structures of the products thus obtained were confirmed by spectral studies.