Abstract
AbstractNovel dispiropyrrolothiazole derivatives (IV) and (VI) are synthesized under mild reaction conditions in a complete regio‐ and stereoselective manner using three‐component 1,3‐dipolar cycloaddition reactions of cyclic diketones (I) or (V) with thiazolanecarboxylic acid (II) and arylidenepyrolidinedione (III) The dispiropyrrolothiazole derivatives (IVf) and (IVg) are found to exhibit significant antimycobacterial activity and emerge as the most promising antitubercular agents.
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