Abstract
The development of new strategies for synthesis of trifluoromethylthiolate compounds is of considerable importance in pharmaceuticals, agrochemicals, and ad- vanced materials. Accordingly, currently much attention is being devoted to the development of effective methods and reagents for their synthesis. In contrast, considerably less effort has been afforded to the development of pre- paring CSeCF3 bonds. Herein we report a concise route to synthesize a family of copper(I) trifluoromethylseleno- late reagents by the reaction of CuI with the Ruppert's re- agent (Me3SiCF3), KF, and elemental selenium in the pres- ence of dinitrogen ligands in CH3CN at room temperature. The reagent (Cu(bpy)(SeCF3))2 was proven to be air-stable and highly efficient for nucleophilic trifluoromethylthsele- nolation of a broad range of (hetero)aryl halides and alkyl halides. This method represents a powerful protocol for the construction trifluoromethylselenolate compounds.
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