Abstract
The reaction of hydrazine with dibenzofuran-1, 2-dicarboxylic anhydrides followed by treatment with acetic acid resulted in the formation of 1, 4-dioxo-1, 2, 3, 4-tetrahydrobenzofuro[3, 2-f]phthalazines. Dibenzofuran-1, 2-dicarboxylic anhydrides were prepared by the Diels-Alder reaction of 2-alkenyl benzofurans and maleic anhydride followed by oxidative aromatization. Chlorination of 1, 4-dioxo-1, 2, 3, 4-tetrahydrobenzofuro[3, 2-f]phthalazines and subsequent nucleophilic substitution afforded 1, 4-dialkoxybenzofuro[3, 2-f]phthalazines. These compounds were subjected to cytotoxicity assay against L1210 mice leukemia as analogues of methoxyllipticines.
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