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Abstract
Tertiary cyanopropargylic alcohols undergo tandem reaction with thiophene-2-carboxylic and benzo[ b ]thiophene-2-carboxylic acids under microwave irradiation (MeCN, Et 3 N, 100 °C, 2.5–16 h) to afford 4-cyano-5-thienylfuran-3(2 Н )-ones in 69–89%. The cyano function of the synthesized furanones is readily hydrolyzed (aq EtOH, KOH, 20–25 °C, 24 h) to give quantitatively the corresponding amides, 5,5-dialkyl-4-oxo-2-(2-thienyl)-4,5-dihydrofuran-3-carboxamides.
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