Abstract
Abstract Preparation of a uridine derivative bearing both diethylphosphono and methanesulfonate substituents at the 3′-position has been accomplished by reaction of the corresponding α-hydroxy phosphonate with methanesulfinyl chloride and subsequent oxidation. While this methanesulfonate did not undergo elimination under standard reaction conditions, treatment with TBAF results in a novel rearrangement leading to the corresponding 2′-phosphate.
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