ChemInform Abstract: Synthesis and Characterization of Amphiphilic Platinum and Palladium Complexes Linked to Perfluoroalkylated Side-Chain Disubstituted Bipyridines.

Abstract

Abstract The synthesis and characterization of three series of cis -dichloro-[4,4′-bis[( F -alkyl)alkyl]-2,2′-bipyridine], cis - dichloro-[4,4′-bis[( F -alkyl)alkyloxycarbonyl]-2,2′-bipyridine] and cis -dichloro-[4,4′-bis[[2″-( F -alkyl)ethenyl]alkyloxycarbonyl]- 2,2′-bipyridine]-platinum(II) or -palladium(II) complexes are described. These new amphiphilic perfluoroalkylated derivatives, as potential antitumor agents, were designed to be incorporated into liposomes and, more particularly, into injectable fluorocarbon emulsions.