Abstract
Epoxides (6) and (7), topologically related to the carbapenem antibiotics, were designed as potential alkylating inhibitors of the bacterial D,D-peptidases. The olefinic precursors (8-9) were readily prepared, in three steps, by coupling the Wittig reagent (13) with the aldehyde synthons (10) or (11) resulting from diastereoselective aldol condensations. Epoxide (7) showed a weak anti-beta-lactamase activity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
