ChemInform Abstract: Synthesis and Biological Activity of 3,4-Disubstituted 2- Aminopyridines and 2-Pyridones.

Abstract

In our earlier investigation [7] of 2,3,4-trisubstituted pyridines with the amino and amidino groups at the 2and 4-positions, we discovered compounds having analgetic activity. In continuation of this work, using the previously developed scheme [i], we have now carried out the synthesis of a new group of pyridine derivatives (la-d). The starting enaminoamides (II) were obtained by the reaction of cyanoacetamide with N,N-dimethylacetamide diethylacetal, followed by transamination of the enamines obtained with aromatic amines [2].;