Abstract

Novel indolo[3, 2-b]quinolines (1d-g), introduced at the 7-position with an N-glycosylamino group, were prepared and thier antitumor activities against leukemia P388 in mice were examined. The N-Galactopyranosylamino derivative (1e) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C>333%, cure 5/6) than lead compound 1a.

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