ChemInform Abstract: Study of New Reactions Catalyzed by Copper(I) Complexes: Investigation of Domino Catalysis‐ and Dual Catalysis‐Type Reactions

Abstract

In this thesis we are going to first discuss the application of a copper hydride system, which was previously developed in our lab, to new Michael acceptors bearing a nitrogen group on the double bond. We are equally going to illustrate the development of a new cooperative dual catalysis strategy based on a CuI/Pd0 system. This strategy allowed us to successfully access α-allylated ketones diastereoselectively as well as enantioselectively. In a later point, we are also going to examine the development of two synthetic pathways to generate unprecedented (NHC)CuI bifluoride complexes. We tested the activity of these complexes in several known CuI-catalyzed reactions, and consequently established the first CuI-catalyzed diastereoselective allylation of (R)-N-tert-butanesulfinyl aldimines. The method enables efficient, simple and general synthesis of enantiomerically enriched homoallylic amines at room temperature in high yields.