ChemInform Abstract: Studies on the Synthesis of Specifically Fluorinated 4‐Aminopyridine Derivatives by Regioselective Nucleophilic Aromatic Substitution and Catalytic Hydrodefluorination.

Abstract

AbstractWhile pentafluoropyridine (Ib) gives always the 4‐aminated products, trifluoropyridine (Ia) gives regioisomeric mixtures favouring the 4‐aminated product in dependence of bulkiness of the secondary amine reactant.