Abstract

Abstract Puwainaphycins A–E, one of which (C) is a potent cardioactive agent in isolated mouse atria, are cyclic decapeptides that have beeen isolated from a terrestrial blue-green alga Annabaena sp. BQ-16-1. The structures of puwainaphycins A–E, including most of the stereochemical features, have been elucidated by a combination of spectral and chemical methods.

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