Abstract
Abstract An efficient and versatile method for the stereospecific construction of α,ω- cis - and α,ω- trans -disubstituted oxepane skeletons is described. Cyclization of the hydroxy epoxides promoted by a (Bu 3 Sn) 2 O/Zn(OTf) 2 system proceeded via an S N 2 process and exo mode selectivity regardless of the configuration of the hydroxyl and the epoxy groups to provide the corresponding oxepanes in excellent yields.
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