Abstract
Abstract A tandem approach for the regio- and stereoselective synthesis of oxazolo-fused pyrroloquinolines 3a – l via the reaction of o -alkynylaldehydes 1a – i with chiral amino alcohols 2a – c under mild reaction conditions is described. The possible participation of the pyridine ring in the regioselective formation of 5- exo - dig cyclized products was supported by the controlled experiments. The structures and stereochemistry of the products were confirmed by NOESY and X-ray crystallographic studies.
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