Abstract
Trimethylsilylacetylene undergoes clean cis-addition to alkynyl sulfones or esters 1 in the presence of catalytic palladium acetate and tri(2,6-dimethoxyphenyl)phosphine to give (E)-1-sulfonyl (or ethoxycarbonyl)-4-trimethylsilyl-substituted 1,3-enyne 2 in excellent yields. The cross-coupling reaction of (E)-1-sulfonyl (or ethoxycarbonyl)-4-trimethylsilyl-substituted 1,3-enyne 2 with (E)-alkenyl iodides 3 in the presence of Pd(PPh3)4 and tris(diethylamino)sulfonium trimethyldifluorosilicate (TASF) affords stereoselectively (1E,5E)-1-sulfonyl (or ethoxycarbonyl)-substituted 1,5-dien-3-ynes 4 in good yields.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
