Abstract
The recently described FMOC/4-AMP technique for rapid continuous solution synthesis of peptides involving coupling by crystalline FMOC amino acid chlorides and deblocking via 4-(aminomethyl)piperidine (4-AMP) has been extended to the synthesis of a varied number of tachykinin peptides. Removal of excess acid chloride during the coupling step was simplified by use of 4-AMP for this purpose as well as for the deblocking step. Use of this modified technique gave purer crude products and higher yields. Crude products obtained by the modified procedure were often of greater than 95% purity
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