Abstract
The results of a detailed study of the propionylation of anisole over various medium and large pore zeolites such as H ZSM-5, H-bela. H-Na-beta. H-mordenite. H-Y and H-RE- Y are presented and discussed. In addition, homogenous catalysts and amorphous Si02-AI20J are also included for comparison, The catalyst and process parameters are optimised to enhance the conversion of propionyl chloride(PC) and selectivity to 4-methoxypropiophenone(4-MOPP). Methoxy propiophenones are found to have wide applications in the area of fine chemical synthesis. They are usually prepared by the Friedel-Crafts acylation of anisole with propionyl chloride/propionic anhydride using AICI, catalysr'r':'. The use of various types of catalysts like ZnCh, FeCh 4 ,5, H3P04 6 , and cobalt (11) chloride have been reported recently in the liquid phase propionylation of anisole. Zeolites due to their shape-selectivity, therrnostability, ease of separation from the products and the regeneration of the deactivated catalysts, have been widely used in the field of petrochemistry. However, the use of zeal ite catalysts in fine organic synthesis and particularly in the acylation and alkylation reactions of aromatics is limited. Herein we report the results obtained in the propionylation of anisole under various reaction conditions and on the effects of some catalyst variables on catalyst performance. The results obtained over zeolite H-beta are also compared with the Lewis acid catalyst, AICh.
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