ChemInform Abstract: PREPARATION OF OPTICALLY PURE α‐METHYL‐α‐AMINO ACIDS VIA ALKYLATION OF THE NICKEL(II) SCHIFF BASE OF (R,S)‐ALANINE WITH (S)‐2‐N‐(N′‐BENZYLPROLYL)AMINOBENZALDEHYDE

Abstract

Chiral nickel(II) complexes of Ala with (S)-2-N-(N′-benzylprolyl)aminobenzaldehyde [(S)-bba] were alkylated with alkyl halides and the diastereoisomeric complexes formed were separated on SiO2; their decomposition led to the isolation of enantiomerically pure (R)- and (S)-α-alkyl-α-amino acids with recovery of the initial (S)-bba.