Abstract
An efficient procedure for the one-pot synthesis of 1,4-disubstituted 1,2,3-triazole derivatives has been developed by the ‘click’ reaction of azides generated in situ from anilines or amines and terminal acetylenes catalyzed by the polymer anchored Cu(II) catalyst in water without using any additives. The polymer anchored Cu(II) catalyst was synthesized and its catalytic activity was evaluated in the Huisgen [3 + 2] cycloaddition reaction for the first time. This protocol offers several advantages like low catalyst loading, high yields, clean reaction, recyclability of the catalyst, reaction in water, no use of hazardous organic solvents for the purification of product, and one-pot synthesis of triazoles from anilines or amines.
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