Abstract
A facile, metal-free protocol has been developed for the remote trifluoromethylation of 8-aminoquinoline scaffolds on the C5 position, which is difficult to functionalize. In this method, 8-aminoquinolineamides reacted with an inexpensive and commercially available CF3 source (Langlois reagent) to give a wide range of trifluoromethylated aminoquinolineamides.
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