ChemInform Abstract: Organocatalytic Asymmetric Oxy‐Michael Addition to a γ‐Hydroxy‐α,β‐Unsaturated Thioester via Hemiacetal Intermediates.

Abstract

AbstractMichael addition of carbonyl compounds (II) towards γ‐hydroxy‐α,β‐unsaturated thioester (I) proceeds smoothly in the presence of a bifunctional Cinchona alkaloid—thiourea catalyst to afford hemiacetals (III)/(IV) with moderate diastereo‐ and high enantioselectivity.