ChemInform Abstract: One‐Pot Synthesis of 5‐Fluoroalkyl‐5‐hydroxy‐4‐hydroxyimino‐1‐isonicotinoyl‐4,5‐dihydro‐1H‐py razoles and Their Tuberculostatic Activity.

Abstract

AbstractPolyfluoroalkyl‐containing diketones (I) are treated with sodium nitrite in acetic acid to yield the corresponding hydroxyimino derivatives as intermediates, which are reacted with isoniazid (II) without isolation to provide the cyclic dihydropyrazoles (III).