ChemInform Abstract: Novel 1-Trifluoromethyl Substituted 1,2-Ethylenediamines and Their Use for the Synthesis of Fluoroquinolones.

Abstract

Abstract A common approach to the synthesis of 1-trifluoromethyl-1,2-ethylenediamines was developed. Based on these original building blocks the new derivatives of N -substituted fluoroquinolones bearing the trifluoromethyl group were obtained. Through-space transmitted coupling constants 7 J F–F between the trifluoromethyl group and F-8 were measured in the 19 F NMR spectra of all fluoroquinolones examined and assigned unequivocally by using 19 F{ 19 F} double resonance technique.