Abstract
Abstract Novel sesquiterpene-neolignans, eudesobovatos A (1) and B (2), eudesmagnolol (3), eudeshonokiols A (4) and B (5), clovanemagnolol (6), and caryolanemagnolol (7), have been isolated from the bark of Magnolia obovata. Their structures were elucidated to be sesquiterpenes (eudesmol, 4,4,8-trimethyltricyclo [6.3.1.02,5] dodecane-1,9-diol, and clovanediol) combined through ether bond with neolignans such as obovatol, honokiol, and magnolol on the basis of spectral data, degradation, and/or synthesis. Compounds 1, 6, and 7 were found to exhibit interesting neurotrophic activity on a neuronal cell culture system derived from fetal rat hemisphere.
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