Abstract
The bifunctional N-heterocyclic carbene catalyzed [3 + 4] annulation of enals and 5-alkenyl thiazolones was developed, giving the corresponding thiazole-fused e-lactones in high yields with excellent diastereoselectivties and enantioselectivities. The thiazole-fused e-lactone could be isomerized to the spirocyclic thiazolone–cyclopentanone without erosion of enantioselectivity.
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