ChemInform Abstract: Metal-Ion NMR Studies of Ion Binding

Abstract

Publisher Summary This chapter covers the studies, where nuclear magnetic resonance (NMR) is used as a tool to investigate the interaction between an ion and another ion or a molecule or an aggregate. The work dealing with ion binding is discussed in the chapter. NMR studies of ion binding correspond to the alkali and alkaline-earth ions. Thus, the chapter describes the small ligands, such as alkali metals, alkaline-earth metals, transition metals, and group IIA and IIIA metals. A number of macromolecules have been studied, using a limited number of NMR sensitive nuclei, owing to the size and complexity of the systems. However, of the available nuclei, both the alkali and the alkaline-earth metals have been used extensively. The metal ions that bind to the macromolecules are alkali metals (23Na and 7Li), alkaline-earth metals (25Mg and 43Ca), transition metals (51V), and thallium (205Tl). The ion binding to aggregates and cells occurs through Gramicidin channels. Finally, the chapter gives an account of the whole-cell studies.