ChemInform Abstract: Metal‐Free, Phosphonium Salt‐Mediated Sulfoximination of Azine N‐Oxides: Approach for the Synthesis of N‐Azine Sulfoximines.

Abstract

Herein, we report a simple and metal-free method for the synthesis of N-azine sulfoximines by the nucleophilic substitution of azine N-oxides with NH-sulfoximines. The present method works at room temperature with wide functional group compatibility and gives several unprecedented N-azine sulfoximines. The reaction conditions were also found suitable with enantiopure substrates and furnished products without any racemization. It also finds an application in the sulfoximination of azine-based functional molecules such as 2,2′-bipyridine, 1,10-phenanthroline, and quinine.