Abstract
Abstract Two novel tetramic acids named melophlins A ( 1 ) and B ( 2 ) were isolated from the marine sponge Melophlus sarassinorum, and the absolute stereostructures were elucidated on the basis of chemical and physicochemical evidence. Melophrins A ( 1 ) and B ( 2 ) induced reversion of the tumorous phenotype of ras -transformed NIH3T3 cells to normal at the concentration of 5 μg mL −1 .
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