Abstract
Abstract A series of l -prolinamide derivatives have been evaluated as potential organocatalysts for aldol reactions. To synthesize these catalysts, a novel and simple route has been developed using proline N -carboxyanhydride (proline-NCA). A new catalyst with a trifluoromethyl-sulfonamide group has been found exhibiting excellent diastereoselectivity ( anti / syn : 97/3) and enantioselectivity (99% ee) with 10 mol % loading and being easily recyclable in water.
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