ChemInform Abstract: Kinetic Resolution of Racemic α‐Hydroxyphosphonates by Asymmetric Esterification Using Achiral Carboxylic Acids with Pivalic Anhydride and a Chiral Acyl‐Transfer Catalyst.

Abstract

A practical protocol is developed to directly provide chiral α-acyloxyphosphonates and α-hydroxyphosphonates from (±)-α-hydroxyphosphonates utilizing the transacylation process to generate the mixed anhydrides from acid components and pivalic anhydride in the presence of organocatalysts (s-value = 33–518).