Abstract
The direct coupling of sp3 C–OH bond of N-heterocyclic aminols with sp2 C–H bond of electron rich arenes have been achieved via iron catalyzed dehydrative cross coupling strategy. This novel protocol provides an efficient and straight forward route to access biologically important C4-aryl-3,4-dihydroquinazoline derivatives through the reaction of C4-hydroxy-3,4-dihydroquinazoline/aminol with phenol and aniline derivatives under mild reaction conditions.
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