ChemInform Abstract: Iridium‐Catalyzed Asymmetric [3 + 2] Annulation of Aromatic Ketimines with Alkynes via C—H Activation: Unexpected Inversion of the Enantioselectivity Induced by Protic Acids.

Abstract

AbstractA cationic iridium/binap catalyst enables the asymmetric [3 + 2] annulation of cyclic N‐acyl ketimines with internal alkynes via C—H activation to give spiroaminoindene derivatives with high enantioselectivity.