ChemInform Abstract: Hydrosiloxane—Ti(OiPr)4: An Efficient System for the Reduction of Primary Amides into Primary Amines as Their Hydrochloride Salts.

Stephane Laval,Wissam Dayoub,Marc Lemaire,Leyla Pehlivan,Gerard Mignani,Alain Favre‐Reguillon,Estelle Metay,Dominique Delbrayelle

doi:10.1002/chin.201147061

ChemInform Abstract: Hydrosiloxane—Ti(OiPr)4: An Efficient System for the Reduction of Primary Amides into Primary Amines as Their Hydrochloride Salts.

Stephane Laval, Wissam Dayoub + Show 6 more

https://doi.org/10.1002/chin.201147061

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Journal: ChemInform

Publication Date: Oct 27, 2011

Affiliation: French National Centre for Scientific Research, Lyon College, Claude Bernard University Lyon 1

#Aliphatic Primary Amides #Reduction Of Amides + Show 8 more

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Abstract

A simple and useful method for the reduction of primary amides into the corresponding amines using a polymethylhydrosiloxane (PMHS)–Ti(OiPr)4 reducing system is described. Aromatic as well as aliphatic primary amides are reduced in high selectivity and excellent yields. The reduction could proceed via dehydration of the primary amide group into the corresponding nitrile which is then reduced into the corresponding primary amine.

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