Abstract
The kinetic resolution of a series of tertiary acetylenic acetate esters using the lipase from Candida cylindracea has been explored. Compounds 6c and the trifluoromethyl acetate 6e have been resolved with high enantiomeric enrichments. Several other tertiary acetate esters carrying a CF3 group have been investigated which proved inert to enzymatic hydrolysis. From these results and published data, we are able to propose a predictive model for identifying the preferred enantiomer of secondary and tertiary trifluoromethyl acetate esters for this lipase.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
