Abstract
Abstract Asymmetric aldol reaction of (+)-tricarbonyl(η 6 -2-trimethylsilylbenzaldehyde)chromium(0) complex ( 4 ) with titanium enolate of S-tert -butyl benzyloxyethanethioate ( 10 ) provided, after consecutive desilylation and decomplexation, anti -aldol product 15 in a highly stereoselective manner. Anti -product 15 was subsequently converted to (2R,3S)- N -benzoyl- and N-tert -butoxycarbonyl-3-phenylisoserine methyl esters ( 23 and 24 ), C-13 side chain analogues of taxol ( 1 ) and taxotere ( 2 ).
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