Abstract
A highly enantioselective Michael addition of 3-aryloxindole to phenyl vinyl sulfone catalyzed by a quinine-derived bifunctional amine–thiourea-bearing sulfonamide as multiple hydrogen-bonding donor catalyst has been investigated. The corresponding adducts, which contain a chiral quaternary carbon center at the 3-position of the oxindole, were obtained in moderate-to-good yields (52–86 %) with high-to-excellent enantioselectivities (83–98 % ee).
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