ChemInform Abstract: FT‐IR Spectroscopic Evidence of Sugar Ring Conformational Changes in GpC and CpG on Platination and Intercalation

Abstract

Abstract An FT-IR spectroscopic study concerning changes in the conformation of sugar in the dinucleotides; GpC and CpG, on platination and intercalation is presented. The results are compared with the FT-IR spectral data of 5′-CMP, 5′-GMP, 3′-GMP and their metal adducts. The spectra of free GpC, free CpG, proflavine-GpC, proflavine-CpG, and cis -[Pt(NH 3 ) 2 (GpC) 2 ] 2+ exhibit the diagnostic band at 800 cm −1 which was assigned to a sugar phosphate vibrational mode and diagnostic of C3′- endo sugar pucker. In the case of 9-aminoacridine-GpC and cis -[Pt(NH 3 ) 2 (CpG] + the diagnostic bands of the C2′- endo and C3′- endo conformations are observed at 810–820 cm −1 and near 800 cm −1 respectively. The results are in good agreement with X-ray data. The infrared diagnostic bands are important for distinguishing the sugar pucker conformational changes.