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Abstract
A highly regio- and stereoselective proto- col for the synthesis of vicinal quaternary and terti- ary stereocenters has been developed. The 6'-OH Cinchona alkaloids (BnCPN or BnCPD) at low cata- lyst loading (0.5-5 mol%) catalyze the Michael addi- tion of trisubstituted carbon nucleophiles to nitro- dienes in good to excellent yield (up to > 99), high enantioselectivity (up to 99% ee) and high diastereo- selectivity (up to > 99:1 dr) under mild reaction con- ditions.
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