Abstract

Abstract The stereoselective acylation of meso piperidines 3a , b by vinyl acetate (solvent and acyl donor) in the presence of Candida antarctica lipase gave the corresponding (2 S ,6 R ) and (2 S ,4 R ,6 R ) monoesters 2a , b in high enantiomeric purity. (5 S ,9 S )-(+)-Indolizidine 209D was prepared in eight steps from (2 S ,6 R )- 2a .

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