Abstract
The dynamic kinetic resolution of alpha-substituted racemic beta-lactams by alcoholytic ring-opening, catalyzed by immobilized lipase B from Candida antarctica is described. With this process, a variety of racemic a-substituted N-Cbz-azetidinones (Cbz = benzyloxycarbonyl) was transformed to the corresponding N-Cbz-protected beta(2)-amino acid allyl esters with high enantioselectivity (up to 99%) and high yields (up to quantitative) at room temperature.
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