Abstract
It was found that in the presence of 20 mol % HCOOH, (S)-prolinol silyl ether organocatalyst bearing a long chain only in 2 mol % loading could catalyze the asymmetric Michael reaction of various aldehydes with trans-nitroalkenes at room temperature in the presence of water, giving the desired adducts in excellent yields with high diastereoselectivities and excellent enantioselectivities (up to >99% ee).
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