ChemInform Abstract: Direct Enantioselective Amination of α‐Ketoester Catalyzed by Tertiary Amine Thiourea: A new Approach to Chiral α‐Hydroxy‐β‐amino Acid.

Ji‐Ya Fu,Li‐Xin Wang,Yong‐Yuan Gui,Qi‐Lin Wang

doi:10.1002/chin.201542112

ChemInform Abstract: Direct Enantioselective Amination of α‐Ketoester Catalyzed by Tertiary Amine Thiourea: A new Approach to Chiral α‐Hydroxy‐β‐amino Acid.

Ji‐Ya Fu, Li‐Xin Wang + Show 2 more

https://doi.org/10.1002/chin.201542112

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Journal: ChemInform

Publication Date: Oct 1, 2015

Affiliation: Henan University, University of Chinese Academy of Sciences, Chengdu Organic Chemicals (China), Chinese Academy of Sciences

#Chiral Tertiary Amine Thioureas #Tertiary Amine Thiourea + Show 8 more

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Abstract

Abstract A highly enantioselective amination of α-ketoesters catalyzed by chiral tertiary amine thioureas was reported to afford α-hydroxy-β-amino acids with two continuous stereocenters in high yields (up to 90%) and enantioselectivities (up to 93% ee).

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