Abstract
New strategies for the syntheses of the pumiliotoxin (PTX) A dendrobatid alkaloids have been developed which are based on palladium-catalyzed carbonylation, palladium-catalyzed cross-coupling reaction, and nickel-chromium-mediated cyclization. Application of these methodologies to the asymmetric total syntheses of (-) -PTX 209F, (-) - PTX 225F, (+) -PTX A, (+) -allo-PTX 267A, (+) -allo-PTX 339A, and (+) -homo-PTX 223G is described.
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