Abstract
Sequential chlorination/fluorination of aromatic trifluoroacetylated ketones gives 1-aryl 2-chloro-2,4,4,4-tetrafluorobutan-1,3-dione hydrates that are used for the synthesis of ketones and alkenes exhibiting a terminal bromochlorofluoromethyl group. The hydrates undergo detrifluoroacetylative cleavage and subsequent bromination in the presence of a copper(II) bisoxazoline catalyst, K2CO3, and NBS at room temperature. The corresponding bromochlorofluoromethyl ketones can be applied in Wittig and Horner–Wadsworth–Emmons reactions and dibromoalkenylations.
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