ChemInform Abstract: Cu(I)‐Catalyzed Cross‐Coupling of Terminal Alkynes with Trifluoromethyl Ketone N‐Tosylhydrazones: Access to 1,1‐Difluoro‐1,3‐enynes.

Abstract

C–C Bond formation and β-F elimination have been achieved in a Cu(I)-catalyzed cross-coupling reaction of terminal alkynes and trifluoromethyl ketone N-tosylhydrazones. The reaction represents an efficient synthesis of 1,1-difluoro-1,3-enyne derivatives. Mechanistically, the migratory insertion of the copper carbene intermediate leads to the C–C bond formation, which is followed by C–F bond cleavage.